And again thinking further ...
I suppose your question arose because of this topic / post :
Re: How to compare XXhighend Settings. That assumed, your sequence can be Alt-X, Press Pause, change setting, press Play.
At least that is how I do it.
Even more conveniently would be : Alt-X, change setting(s), press Pause, tap on the time bar at the bottom if you like to proceed a bit further because changing the setting(s) took you 30 seconds and you don't want to repeat all of those 30 seconds, press Play.
The way I do it (first option above) gives you a quite randomized A-B situation because you will be repeating these last 30 seconds.
Either of these options give the least down time (no-music-time) because music commences when you are changing the settings.
Peter